Gastroenteritis is the second most common illness after the common cold and a leading cause of death worldwide across all age groups. Globally, diarrhea accounts for approximately 2 million deaths in children under 5 years old per year, or 19% of total child deaths. Multiple types of pathogens cause gastroenteritis including viruses, bacteria, or parasites. For many years, clinical laboratories typically rely on the combination of conventional microbiological methods and molecular methods which require a longer turnaround time causing delays in the identification of gastrointestinal pathogens. Thus, the rapid identification of diarrheal pathogens is essential to clinical practice.
The Gastrointestinal Pathogen Panel (GPP) is an FDA 510(K) cleared multiplex assay integrated with multiplex chip code technology. The GPP can simultaneously detect and identify multiple bacteria, viruses, and parasites extracted directly from unpreserved stool samples or stool preserved in Cary-Blair transport medium obtained from individuals with signs and/or symptoms of gastrointestinal infection. The turnaround time of GPP is usually 24-48 hrs after sample receiving, or the same day if it's STAT case. Thereby, the GPP can quickly provide qualitative diarrhea-causing pathogens results to physicians to facilitate the appropriate treatment of patients and reduce the inappropriate use of drugs.
17 pathogens identified:
▪ Campylobacter (C. jejuni, C. coli)
▪ Clostridium difficile toxin A/B (fresh specimens only)
▪ Enteroaggregative E. coli (EAEC)
▪ Enterotoxigenic E. coli (ETEC): LT/ST
▪ Shiga-toxin producing E. coli (STEC): stx1/stx2
▪ E.coli O157
▪ Shigella spp. /Enteroinvasive E.coli (EIEC)
▪ Salmonella spp.
▪ Vibrio parahaemolyticus
▪ Vibrio spp. (not parahaemolyticus)
▪ Yersinia enterocolitica
▪ Cryptosporidium spp. (C. hominis/C. parvum)
▪ Entamoeba histolytica
▪ Giardia lamblia
▪ Adenovirus 40/41
▪ Norovirus GI/GII
▪ Rotavirus A
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